In this article, I outline thoughts regarding the complexities and possibilities of the next generation of reading intervention for students who do not benefit from typical instructional practices. I ground my recommendations in school-based research and observations conducted primarily in kindergarten through third grade and more recently in Grades 6 through 10. Building on principles and practices that have accrued through experimental research, I discuss the importance of enhancing the impact of reading instruction by reinforcing and articulating connections within and between intervention tiers. Specifically, I focus on the potential of (a) fortified Tier 1 foundations, (b) aligned Tier 1 and Tier 2 interventions, (c) bridged instruction to support critical reading transitions, and (d) flexible, responsive Tier 2/Tier 3 interventions.