This paper examines the use of Response to Intervention (RTI) in early childhood programs, more specifically in preschool settings. The paper proposes that RTI in preschool could focus on alleviating risk factors as it relates to social emotional competence, and reduction of challenging behaviors during early childhood years. A case-study in which RTI is used for challenging behaviors of a child is examined. Further, recommendations for practice in application of Positive Behavior Support (PBS) in preschool are made.