We report the initial findings of an ongoing, long-term investigation into subjective quality of life in Macau, a Special Administrative Region of China. Data were collected via quarterly public surveys (2007 to 2009; n = 8,230), as part of the Macau Quality of Life Report. The main aims of the study were to: (a) ascertain the public's satisfaction with life and with the regional situation in Macau; (b) confirm the utility of the International Wellbeing Index (IWI) as a measure of subjective life quality; and (c) contribute to ongoing discussion in the literature on quality of life in China. The data indicated moderate levels of personal (PWI = 64.4; range 63-66.7) and national (NWI = 59.7; 57.4-63.7) wellbeing across the study period, which implies that residents in Macau are generally satisfied with life. The lowest scores were reported in the first quarter of 2009, a period of great economic uncertainty in Macau and the world, but were positioned within the normative range. The IWI demonstrated good psychometric performance, consistent with previous studies in China and the West, which confirmed its utility. These findings are discussed in relation to the IWI's theoretical underpinnings and the literature.