This article provides recommendations for conducting culturally competent qualitative research with Latino immigrants, a historically exploited group that represents more than half of all U.S. immigrants and is continuously growing. Limited research exists on Latino immigrants despite their large presence in the United States. The authors draw upon their qualitative research experiences to help researchers develop culturally competent awareness, knowledge, and skills in studying Latino immigrants. Recommendations are grounded by integrating Latino cultural values in the research process. Issues related to developing a research team, recruiting participants, using incentives, informed consent procedures, and language issues are addressed. Suggestions for developing interview protocols and conducting culturally competent in-person interviews are provided. (Contains 1 note.)