Pamela High, MS, MD, co-director of the Infant Behavior, Cry and Sleep Clinic at the Brown Center for the Study of Children at Risk, discusses the phenomena of infant crying and the impact it has on families. In most cases, infant crying will peak and resolve in the early months, but infant irritability can increase the risk of maternal depression. In extreme cases, infants who cry excessively are at increased risk for injury from shaken baby syndrome. Thus, parents and caregivers need to seek help and support to cope with the challenges of caring for infants who are difficult to console.