Women and their creativity are underrepresented in science. To date, few women have been awarded the Nobel Prize in science. Eleven female Nobel laureates in physics, chemistry and physiology/medicine between 1901 and 2006 were compared with 37 males who received the Nobel Prize in the same area one year prior and one year after the women. Data analyzed included birth order, marital status, children, awards (Fulbright, Rhodes, and number of honorary awards received), highest education level and Nobel mentor. Results indicated that female Nobel laureates were significantly less likely to marry and have children. When female laureates had children, they had significantly fewer children than male laureates. Female laureates also had fewer publications than their male counterparts. Our findings suggest that eminent women scientists tend to choose the pursuit of scientific discovery over starting families more often than eminent male scientists. More resources are needed in order to nurture and enhance the recruitment and retention of women in science, technology, engineering and mathematics (STEM). (Contains 1 table.)