The subject of the research is the planning, implementation and evaluation of the program about prevention of the use of psychoactive substances among students 5-7 grade. The study was conducted by survey method with 314 teachers who teach in twenty-six schools. The qualification of the teachers to work with the program about prevention was studied in the lesson of the class. We studied the forms, through which the preventive activity, topicality, the methods used and course curricula for hours in individual classes were implemented. It was found that there was an interaction between the various recipients of the preventive activity. The preparation and qualification of the teachers to work on a program for the prevention of the use of alcohol and tobacco products was studied in the lesson of the class. We pointed out some problematic aspects and guidelines for development of the preventive activity.