This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center. His research has been pushing back the frontiers of giftedness by revealing intriguing connections between neuroscientific investigations and mathematical high ability. Here, in light of his research, he describes the difference between the brain of a mathematically gifted adolescent and one of more "average" math ability. He also discusses the studies that led him to the conclusions about enhanced development and reliance on the right hemisphere during information processing in the math-gifted brain.