The current study focuses on the contribution of the Big Five personality traits to the development of self-efficacy and outcome expectations regarding selection of a high school major among 368 Israeli adolescents (Mage = 16.07, SD = 0.41). Structural equation analyses showed that higher levels of conscientiousness and extraversion and lower neuroticism contributed to higher self-efficacy. In contrast, higher levels of conscientiousness and neuroticism and lower extraversion contributed to higher outcome expectations. These findings expand our understanding regarding personality characteristics serving as antecedents of self-efficacy and outcome expectations and sets important implications for career interventions with adolescents.