This study examined relationships among acculturative stress, grade point average satisfaction, maladaptive perfectionism, and depression in 52 East Asian international students and 126 North American students. Results indicated that a combined effect of perfectionism and acculturative stress accounted for more than 30% of the variance related to depression. Implications include the importance of attending to perfectionism and acculturative stress for improving the overall well-being of East Asian international students.