In 1925, A.J. Balfour, first Earl Balfour and author of the famous "Balfour Declaration", attended the inauguration of the Hebrew University in Jerusalem. His education and experience of foreign policy equipped him to take a prominent role. However, the conditions of strife-torn Palestine weighed heavily upon him, and raised wider interests of imperial concern. This essay recounts the circumstances leading to his visit, and suggests that, whatever the region's political destiny, Balfour's vision of science-based economic development would play an essential role in crafting its future.