Orthographic influences in spoken word recognition have been previously examined in alphabetic languages. However, it is unknown whether orthographic information affects spoken word recognition in Chinese, which has a clean dissociation between orthography (O) and phonology (P). The present study investigated orthographic effects using event related potentials (ERPs) and an auditory lexical decision task. We manipulated the relationship between the phonology and orthography of the first syllable in each prime-target pair using the following four conditions: P+O+, P+O-, P-O+, P-O-. Importantly, we found significantly reduced N400 amplitudes when an item was preceded by an orthographically similar prime. In addition, these reduced N400 amplitudes were positively correlated with participants' reading skill. The findings indicate that orthographic information is activated automatically during Chinese spoken word recognition, supporting the theory that there is a reciprocal connection between speech and print. (Contains 5 tables and 4 figures.)