The national open universities of China and India are unique adaptations of the open university model that emanated from the UK. These institutions have expanded to become the largest universities in the world as measured by current enrollment of approximately four million each. This article comparatively analyzes how these open universities have differentiated themselves from the open university model and from each other amidst similarities of outcome and differences of approach. Historical contexts, national governance of higher education, institutional administration, curriculum and international operations are the foci of analysis. The article contributes to the literature on national and local forces that shape higher education systems and aims to spur collaborations between the institutions in question for mutual benefit.