The purpose of the present study was to examine the psychometric properties, factorial structure, and validity of the Padua Inventory-Washington State University Revision and of the Padua Inventory-Revised in a large sample of patients with obsessive-compulsive disorder (n = 228) and with anxiety disorders and/or depression (n = 213). The five-factor structures of both revisions were not replicated. A 24-item revision, referred to as the Padua Inventory-Palatine Revision (PI-PR), was developed on the basis of both theoretical and statistical considerations. The PI-PR assesses six subscales: Contamination and Washing, Checking, Numbers, Dressing and Grooming, Rumination, and Harming Obsessions and Impulses. The results demonstrate that the PI-PR is a brief, psychometrically sound, and valid measure for the assessment of a broad range of obsessive-compulsive symptoms, which has important advantages over both previous revisions. (Contains 3 notes, 7 tables, and 2 figures.)