The greatest current threat to humanity, most especially in the developing countries of the world, is HIV/AIDS. The first case of HIV/AIDS in Nigeria was in 1986 in Lagos. Due to inaction and denial by the people, there was a rapid but subtle transmission of the virus within Nigeria's various populations and communities. Presently, the disease has been diagnosed in all the 774 local government areas in Nigeria. The trend suggests that there will be a continued increase in the seroprevalence rate of the disease. Going by the trend and the probable impact on the economy, healthcare system, and the polity of the nation, among others if the spread is left unchecked, there is a need for concerted efforts from all the stakeholders at government and NGO level to develop and implement programmes to help slow down the spread, and mitigate the impact of, the disease among Nigeria's large population. One of the leading NGOs in Nigeria is Network on Ethics, Law/Human Rights, HIV/AIDS Prevention, Support and Care (NELA). NELA has implemented a number of projects on HIV/AIDS/STI prevention, training, management, care and support in Nigeria. It has collaborated with many international donors through their Nigerian offices in the past. Currently, NELA collaborates with International HIV/AIDS Alliance (IHAA) in Brighton United Kingdom, to provide support--both financial and technical--to community-based organisations and civil organisations in Southwest Nigeria to carry out different activities on HIV/AIDS Prevention, Support and Care. This article highlights the processes involved in reaching out to other organisations and various target groups by NELA to be able to implement many projects in Nigeria. In doing this, the authors focus on two major areas--NGO support work and support and care for people living with HIV/AIDS. The article reports on a project being funded by the United States Agency for International Development (USAID), Nigeria, through the IHAA. The project deals with technical and financial support for NGOs in South Western Nigeria to mitigate the impact of HIV/AIDS through participatory and community approaches. The project started early in February 2002 with support for ten NGOs. This has now risen to 25 in the five states (Oyo, Osun, Ondo, Ogun and Ekiti) of South Western Nigeria.