In this article, we formulate a nonlinear structural equation model (SEM) that can accommodate covariates in the measurement equation and nonlinear terms of covariates and exogenous latent variables in the structural equation. The covariates can come from continuous or discrete distributions. A Bayesian approach is developed to analyze the proposed model. Markov chain Monte Carlo methods for obtaining Bayesian estimates and their standard error estimates, highest posterior density intervals, and a PP p value are developed. Results obtained from two simulation studies are reported to respectively reveal the empirical performance of the proposed Bayesian estimation in analyzing complex nonlinear SEMs, and in analyzing nonlinear SEMs with the normal assumption of the exogenous latent variables violated. The proposed methodology is further illustrated by a real example. Detailed interpretation about the interaction terms is presented.