Interdisciplinary teaching is a great way to focus on overarching concepts and help students make connections across disciplines. Historically, art and science have been connected disciplines. The botanical prints of the 18th and 19th centuries and early work with microscopes are two examples of a need for strong artistic skills in the science community. The study of cells and the use of microscopes are often taught in middle school using traditional methods. Although schools with the resources to purchase microscopes provide the requisite hands-on experience, the lessons are typically formulaic and allow for little student creativity. This article describes a miniunit that supplements a unit on the study of cells and the use of microscopes, which introduces the fundamentals of cellular biology. The miniunit promoted an inquiry approach to learning and was closely connected to the science and art content being addressed in both subject areas. (Contains 5 figures and 1 resource.)