The study purpose is to examine the impact of early substance use on lifetime and past year contraction of sexually transmitted diseases (STDs), including chlamydia, gonorrhea, herpes, and syphilis. A secondary analysis of the 2012 National Survey on Drug Use and Health (N = 52,529) was conducted to determine if lifetime or past year STD contraction differed based on demographic differences. Lifetime and past year contraction based on first use of substance before age 21 differed based on sex, race/ethnicity, age, alcohol, marijuana, crack, and sedatives. Recommendations for future studies are included.