This study investigated the change in critical thinking (CT) skills of baccalaureate nursing students who were educated using a Think-Pair-Share (TPS) or an equivalent Non-Think-Pair-Share (Non-TPS) teaching method. Critical thinking has been an essential outcome of nursing students to prepare them to provide effective and safe quality care for patients. Think-Pair-Share is a cooperative discussion strategy that provides students with adequate time to think in order to increase their quality of responses. Students become actively involved in thinking about the concepts presented in their discussion. Ninety one students participated in this study. Forty six (50%) of the participants were included in the control group (Non-TPS) and 45 (50%) were included in the experimental group (TPS). The participants were sophomore-level generic accelerated baccalaureate nursing students enrolled in the same Health Assessment nursing course. The HESI critical thinking test was the tool used before (Pretest) and after (posttest) the course to collect data about student's CT skills. The study used a quasi experimental design. The independent sample t test and Mann-Whitney test were used to analyze the data. Findings revealed a significant increase in CT over time, throughout the 17-week course, with the use of TPS teaching/learning strategy. The results suggest that TPS is an effective strategy to foster CT of nursing students and could be used by educators to foster learners' CT in their courses. The study has significant implications on education, nursing practice, and research.