In the present study, the authors evaluated the effects of increasing degrees of simulated non-content-based (random or fixed) responding on scores on the newly developed Variable Response Inconsistency-Revised (VRIN-r) and True Response Inconsistency-Revised (TRIN-r) scales of the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF; Y. S. Ben-Porath & A. Tellegen, 2008) and compared the performance of these new scales with the existing VRIN and TRIN scales of the MMPI-2 (J. N. Butcher et al., 2001). The results support the interpretation of VRIN-r and TRIN-r scores as measures of random and fixed responding, respectively. Furthermore, the authors examined how scores on the Restructured Clinical (RC) scales (A. Tellegen et al., 2003) are affected by increasing levels of non-content-based responding and offer practical interpretive recommendations for test users. Finally, the results of the present study indicate that RC validity coefficients are relatively robust in the face of moderate degrees of non-content-based responding. (Contains 5 tables.)