The Technology-Enhanced Learning in Science (TELS) center, a National Science Foundation-funded Center for Learning and Teaching, offers research-tested science modules for students in grades 6-12 (Linn et al. 2006). These free, online modules engage students in scientific inquiry through collaborative activities that include online investigations, interactive visualizations, and electronic discussions that allow teachers to access detailed accounts of student learning (Williams and Lynn 2003). This paper reports on how the Mitosis and Cell process module worked in a seventh-grade classroom in an urban school. (Contains 6 figures and 2 online resources.)