Relationships between family structure and perceived life satisfaction in overall life and five domains of the Brief Multidimensional Students' Life Satisfaction Scale, family life, friendships, school experience, myself, and where I live were examined among 4,502 Chinese adolescent secondary school students in Hong Kong. Bivariate analyses showed that economic status was not a significant risk factor, but gender, level of study, and migrant status had to be controlled to examine the life satisfaction-family structure relations. Logistic regression analyses found that in overall life, with adolescents living with two parents as standard for comparisons, adolescents living with mother had similar life satisfaction, but those living with father only, and those with no parents, or single parent with other adults had very much higher risk of life dissatisfaction. Specifically, the risks associated with the adverse family structures were most excessive in the domain of "family life".