This guide provides a framework for Acquired Immune Deficiency Syndrome (AIDS) instruction within a comprehensive health education program stressing positive health behaviors. The guide is structured to: (1) provide information to school personnel on how to implement a home/school/community approach to AIDS instruction; (2) provide suggested grade-level cluster lessons that are considered age-appropriate and sequentially developed through objectives and learner outcomes from K-12; (3) stress healthful lifestyles; (4) provide, in grades K-6, a focus on AIDS that will allay fear and concern; (5) stress abstinence in all lessons where methods of prevention are discussed; (6) provide connections to the Health Syllabus and Regents Goals; and (7) provide current information on AIDS. The following information is appended: (1) education law, regulations of the Commissioner of Education, and rules of the Board of Regents; (2) sample adolescent pregnancy prevention projects; (3) information on AIDS and condoms; and (4) compendium of teacher vocabulary lists. (JD)