The issue of antimicrobial resistance in food animal agriculture was addressed by conducting clinical trials to assess alternatives to antimicrobials in dairy calf-raising and developing outreach to three different audiences. Current research was integrated into Extension programs for calf-raisers, animal science and veterinary students, and food animal veterinarians. A complex issue such as resistance in bacteria from the use of antimicrobials in food animal agriculture requires an integrated approach--from the science to its translation to judicious drug use on-farm but also a wide reach, to multiple audiences. (Contains 1 table.)