A unique Alcohol, Tobacco, and Other Drug (ATOD) prevention program called "PALS" (Prevention through Alternative Learning Styles) was implemented with middle school students with the goal of enhancing student knowledge of the harmful effects of ATOD, promoting the use of refusal skills and reducing intentions to use ATOD in the future. Intentions to use were measured at four points: pre-"PALS," post-"PALS," and at 1-year and 2-year follow-ups. Student survey responses were then matched and compared across the four time periods. This article reports on the long-term effectiveness of "PALS" on student intentions to use ATOD in high school. When follow-up surveys of "PALS" students were compared to students not exposed to "PALS" (comparison group), the "PALS" students had significantly lower intentions to use alcohol and tobacco, providing evidence that the "PALS" intervention did have a long-term impact on intentions to use these substances.