In the Fall Semester of 2003, an accredited course for graduate students, entitled "Homosexual Health Social Sciences," was launched at the School of Public Health of Fudan University, located in Shanghai, China. Using participant observation, in-depth interview and document review, this article details the experiences and strategies in establishing the first course on homosexuality in China. Moving beyond biopsychosocial medical mode, the course was designed from the perspectives of humanities and social sciences in the context of HIV/AIDS. Although only a few graduate students enrolled in the course, attendance of the lectures averaged 100 persons, and it has had deep socio-cultural impacts on university students, the gay community and the domestic and international mass media because of its pioneering practice and its teachers' eminent effects. (Contains 2 tables and 1 note.)