The present study examines whether vocational interests, measured by Holland's RIASEC model, and objectively assessed cognitive abilities, were useful in discriminating among various major categories for a sample of 1990 German university students. Interests and specific abilities, in combination, significantly discriminated among major categories and furthermore, ability measures added incremental validity to prediction based on interest measures alone. Logistic regression analyses revealed significant differences in predictor importance between women and men. Furthermore, overall gender differences in interests and cognitive abilities were identifiable within major categories as well. Implications for career counseling are discussed. (Contains 7 tables.)