The purpose of this study was to evaluate the effect of a special sex education program in sexual health on Iranian newly-wed couples. A sample of 64 couples referred to three health centers of Tehran Medicine University, a few months prior to their marriage, were divided into case and control groups. The case group received three lecture sessions given by the researcher. These lectures consisted of different aspects of sexuality such as reproductive and sexual health, the sexuality response cycle and sexual communication. The control group received only the lectures that are presented normally in the marriage preparation program, based on family planning and personal health. Six months after the program, we assessed the sexual satisfaction, healthy behaviors and sexual health of the two groups. The results indicate that the sexual health in the case group is significantly improved compared with the control group. (Contains 5 tables.)