Vaccines are one of the triumphs of modern medicine, relegating many once-fearsome diseases to the history books. Denying access to school has long been the best way to ensure that children get vaccinated, but carrying out any change in immunization policy means a lot of work for school officials. This article discusses the unity of several states, including Maryland, in considering changes to their immunization regimens to include the new vaccine against human papillomavirus, or HPV, as a requirement for public school attendance. In addition to HPV, adolescent vaccines recommended by the Centers for Disease Control and Prevention (CDC), include one against meningitis and a combined booster shot against tetanus, diphtheria, and pertussis. Adolescence is also considered a prime time to catch up on any other vaccines that were missed in early childhood. The author concludes that schools play an important role in implementing vaccination policies, however parents should also have proper knowledge and awareness in this matter.