Little research examines protective behavioral strategies (PBS) use among college high-risk drinking sub-groups. A secondary data analysis of the 2011 National College Health Assessment (n = 18,483 drinkers [13% Greek]) revealed fraternity and sorority members used PBS significantly (p < 0.001) less and reported significantly (p < 0.001) more alcohol-related consequences than non-Greeks. PBS use (ß = -0.31) made the strongest contribution in explaining alcohol-related consequences (i.e., less frequent PBS use resulted in more consequences).