In this pilot study, a genetics-based laboratory exercise using the cyanobacterium Fremyella diplosiphon was developed and trialled with thirteen Natural Sciences undergraduates. Despite most students only having limited prior exposure to molecular genetics laboratory methods, this cohort confirmed that they were able to follow the protocol and create a range of mutants. Supporting evidence that this was a useful exercise was derived from eight of these students going on to full-time laboratory research to study these mutants. In summary, the exercise was considered very useful for improving student learning through practical genetics instruction. (Contains 3 figures and 3 tables.)