Special educators are required to use evidence-based academic and behavioral interventions in their classrooms (U.S. Department of Education, 2010). No rigorous and comprehensive database currently exists to support educators. Within the field of special education, single-subject research is the primary research methodology (Horner, Carr, Halle, McGee, Odem & Wolery, 2005). The lack of a clear standard of quality or method of synthesis of single-subject research has made interpreting the results of the research difficult for teachers, schools, and policymakers (Conroy, Dunlap, Clarke, & Alter, 2005; Mooney, Epstein, Reid, & Nelson, 2003). This article provides an overview of resources available to special educators, an overview of single-subject research, and proposes a process for using this research to guide decision-making at the classroom, program, and school or district level. (Contains 1 figure and 2 tables.)