Students whose religious/spiritual views are incongruent with the theological mission advanced by a university face numerous challenges. A sample of 977 undergraduate students at an evangelical institution was categorized as congruent or incongruent with the theological mission. Both groups were compared to 120 students enrolled at an institution with an explicitly inclusive mission statement. Religious pressure differed among the groups. Incongruent students were also less certain about the truth of religious teachings and slightly more open to valuing other religions than their congruent counterparts. Religious university students reported higher levels of meaning than inclusive students. Implications for both religious and secular universities are provided.