There is a notable lack of manualized comprehensive school-based interventions (CSBIs) for children with high-functioning autism spectrum disorders (HFASDs). This pilot study examined the feasibility and initial efficacy of a CSBI for 12 children with HFASDs, aged 6 to 9 years. Treatment included a 3-week summer preparation program followed by a 10-month CSBI, composed of social skills groups, therapeutic activities, face and voice emotion recognition instruction, an individual daily note, and parent training. Feasibility was supported in high levels of treatment fidelity and teacher- and parent-reported acceptability and satisfaction. Pre-post comparisons suggested that children significantly improved their knowledge of target social skills and ability to identify emotions in facial and vocal expressions. According to parent and teacher ratings, children displayed gains in their use of target social skills and broader social performance, as well as reductions in ASD-related features.