The G-DINA ("generalized deterministic inputs, noisy and gate") model is a generalization of the DINA model with more relaxed assumptions. In its saturated form, the G-DINA model is equivalent to other general models for cognitive diagnosis based on alternative link functions. When appropriate constraints are applied, several commonly used cognitive diagnosis models (CDMs) can be shown to be special cases of the general models. In addition to model formulation, the G-DINA model as a general CDM framework includes a component for item-by-item model estimation based on design and weight matrices, and a component for item-by-item model comparison based on the Wald test. The paper illustrates the estimation and application of the G-DINA model as a framework using real and simulated data. It concludes by discussing several potential implications of and relevant issues concerning the proposed framework.