Various studies have found that electronic books (e-books) promote learning, but few works have examined the use of e-books along with an adaptive reading strategy for children. The current study implemented a method to extract keyword cues from e-books to support e-book reading with the read, recite and review (3R) strategy, and then examined the impact of this on children's reading performance. A pilot work recruited 76 first-graders, developed the related reading tests and questionnaires. These were later used in assessing the effects of different interventions on the reading performances and perspectives of 74 first-graders in the main study. Based on the findings of this work, the 3R strategy can be used as an effective approach to guide children's reading with e-books. In addition, the use of keyword cues incorporated with retrieval practice can provide support with regard to Chinese characters and phonetic information in order to aid children's memorization of the story, thus promoting both phonological awareness and reading comprehension.