A series of studies of potentially-traumatic life-events (PTLE) in children and youth with special needs (CSN) was conducted after parents of 102 CSN from interdisciplinary pediatric clinics listed PTLE at significantly higher rates on the Pediatric Emotional Distress Scale (PEDS) compared to parents 58 students with no diagnoses. Subsequent studies replicated this disparity in 213 5-15 year-olds sampled through school-distributed parent PTLE checklists instead of PEDS. Results from school samples suggested significantly more PTLE in CSN, t (211) = -3.39, p less than 0.001. In both studies some of PTLE reported significantly more in CSN were potentially related to the special needs of the child (e.g., hospitalizations, school problems) but others were not (e.g., traumatic events such as vehicular accidents and disasters). Children exposed to more PTLE were rated as having significantly more behavior problems across measures. Suggested cost-effective screening for PTLE may enable clinicians to enhance differential diagnosis, medical management, and psychosocial interventions for CSN by taking into account PTLE and symptoms related to recent disruptive events.