ERIC Number: EJ976691
Record Type: Journal
Publication Date: 2012-Sep
Pages: 9
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0093-934X
EISSN: N/A
The Neural Basis of Syntactic Deficits in Primary Progressive Aphasia
Wilson, Stephen M.; Galantucci, Sebastiano; Tartaglia, Maria Carmela; Gorno-Tempini, Maria Luisa
Brain and Language, v122 n3 p190-198 Sep 2012
Patients with primary progressive aphasia (PPA) vary considerably in terms of which brain regions are impacted, as well as in the extent to which syntactic processing is impaired. Here we review the literature on the neural basis of syntactic deficits in PPA. Structural and functional imaging studies have most consistently associated syntactic deficits with damage to left inferior frontal cortex. Posterior perisylvian regions have been implicated in some studies. Damage to the superior longitudinal fasciculus, including its arcuate component, has been linked with syntactic deficits, even after gray matter atrophy is taken into account. These findings suggest that syntactic processing depend on left frontal and posterior perisylvian regions, as well as intact connectivity between them. In contrast, anterior temporal regions, and the ventral tracts that link frontal and temporal language regions, appear to be less important for syntax, since they are damaged in many PPA patients with spared syntactic processing. (Contains 5 figures.)
Descriptors: Syntax, Aphasia, Patients, Brain Hemisphere Functions, Neurological Organization, Longitudinal Studies, Diagnostic Tests, Language Processing, Neurological Impairments
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A