This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children. Test-retest reliability was examined in a random subsample of 30 children at a five-week interval. The clinical discrimination of the D-N CAS was also examined by comparing children with and without ADHD (18 children in each group) and by comparing children with and without Chinese reading disabilities (18 children in each group). The current Chinese sample demonstrated a four-factor solution for cognitive performance among children with normal development: Planning, Attention, Simultaneous processing and Successive processing (chi[superscript 2](48) = 91.90, p = 0.000; chi[superscript 2]/df = 1.92, RMSEA = 0.050, GFI = 0.966, CFI = 0.954). Moreover, all subtests of the battery demonstrated acceptable test-retest reliability (r = 0.72-0.90, p less than 0.01) at a five-week interval among the subjects of the small subsample. Children with ADHD performed significantly worse than normal children on the Attention factor (p less than 0.001) and the Planning factor (p less than 0.05) of the D-N CAS, and children with Chinese reading disabilities performed significantly worse than normal children on the Simultaneous processing factor (p less than 0.01), the Successive processing factor (p less than 0.001) and the Planning factor (p less than 0.05) of the D-N CAS. These findings suggested that the current four-factor structure of the D-N CAS was similar to the original factor structure of the test. The latent factor of the D-N CAS was fairly stable across the cultures. Moreover, the D-N CAS can distinguish between children with ADHD or Chinese reading disabilities and normally developed children. (Contains 1 figure and 2 tables.)