The present paper aims to study the relationship between spiritual intelligence and job satisfaction among female high school teachers in Isfahan. It was a descriptive-correlation research. Population included all female high school teachers of Isfahan (2015) in academic year 2013-2014. Sample size calculated was 320 teachers by Krejcie and Morgan's table and using multi stage random sampling method. Pearson correlation coefficient, stepwise regression, and multivariate analysis of variance were used for data analysis. Evidence from this study showed that spiritual intelligence and some of its components creating personal meaning and transcendent consciousness have a significant relationship with job satisfaction. Regression results showed that transcendent consciousness is capable of predicting job satisfaction.