The Northeast United States just experienced one of the region's worst natural disasters. Fortunately, because of the confluence of modern computing power and scientific computing methods, weather forecasting models predicted Sandy's very complicated trajectory and development with a precision that would not have been possible even a decade ago. Many lives were saved as a result of these predictions. When scientific computing first emerged in the 1940s, it dramatically increased the ability of researchers in a small number of scientific and engineering disciplines--such as physics and aerospace engineering--to explore new frontiers in science and to change the paradigm for aircraft design. Today, advances in computer technology, the connectivity enabled by the Internet and the explosion of data, are making high-performance computing central to virtually all enterprises, ranging from cutting-edge science, such as analyzing the human genome, to computer-aided design and manufacturing, forecasting the weather, and even using data from social networks to deduce patterns useful for marketing and political forecasting. Massachusetts is poised to lead this revolution in scientific inquiry and reap the economic gains associated with it. Academic research institutions, technology companies and state government are all working to advance the computational capability and research needed for the discoveries and innovations that lie ahead. This effort is embodied and supported by a state-of-the-art, high-performance computing center tucked into the old mill city of Holyoke, Massachusetts. Powered by a natural power source, the Connecticut River, the Massachusetts Green High Performance Computing Center (MGHPCC) will be a model of efficient and environmentally sustainable design, construction and operations. This article describes how the old mill city leads a new revolution in Massachusetts through MGHPCC.