Presented is a project that developed a competency-based clinical chemistry course for associate degree medical laboratory technicians (MLT) in a medical technology (MT) baccalaureate program. Content of the course was based upon competencies expected of medical technologists at career-entry as defined in the statements adopted in 1976 by the House of Delegates of the American Society for Medical Technology. The course was designed to enable medical laboratory technicians who have developed some, but not all, of the required skills of a medical technologist to augment their knowledge and proficiency in specific units of study rather than complete the entire course. Following an introduction, description of the project and its methodology, appendices are presented on: competencies for MLT and MT students; objectives; pre-test and post-test; lecture outline; and learning experiences, which included the critical care laboratory, SMA 12/60 laboratory, special chemistry laboratory, toxicology laboratory, and endocrinology laboratory. It is suggested that because the primary purpose of competency-based instruction is to clearly define what the student is to learn and how mastery is to be demonstrated, the student must receive frequent assessment of progression toward defined goals. A bibliography is included. (LC)