Educators are regularly challenged to design instruction that motivates learners. If interest is lacking, the challenge can be even greater. Tailoring is a message design technique that could help to stimulate interest and consequently, motivation to learn. Effective tailoring requires the formal assessment of learner characteristics and the integration of those characteristics into a given message. Knowing which elements to tailor, however, should not be left to guesswork. This article describes how a health communications framework guided the design and development of three tailored lesson introductions. A step-by-step description of the framework, how it was used, and the resulting product are shared. (Contain 2 tables and 3 figures.)