Little research attention has been given to the linkage between work-family conflict and career commitment. Likewise, although, theoretical arguments about the moderator effects of mentoring on the relationship between work-family conflict and career attitudes have been made in the literature, no research has investigated this assumption. This study examines the relationship between work-to-family conflict and career commitment and tested the moderating effects of gender and mentoring support in the relationship. Data were obtained from 286 employees in government establishments located in Abuja, Nigeria using a questionnaire. Results indicate that work-family conflict and career commitment have a significant negative relationship. Mentoring influenced the strength of the relationship. The negative relationship became very weak and nonsignificant for employees with high levels of mentoring support, whereas it was significantly stronger for employees with low levels of mentoring support. Contrary to hypothesis, gender was not a moderator. Practical implications of findings and future research directions are discussed. (Contains 2 tables.)