This study examined the effects of cultural-values conflict and parental expectations on the career decision-making difficulties of university students in three cities in China (Beijing, Wuhan, and Hong Kong, N = 1342). The Multidimensional Scales of Individual Traditionality and Modernity (Yang, Yu, & Ye, 1989) were used as a measure of cultural-values conflict and cultural orientation. The Living-Up-to Parental Expectation Inventory (Wang & Heppner, 2002) was used to measure parental expectations. The Career Decision-Making Difficulties Questionnaire (Gati & Saka, 2001) was used as a dependent measure. It was found that levels of cultural-value conflict were associated with higher levels of career decision-making difficulties for students in the Chinese Mainland cities but not for students in Hong Kong. Perceived parental expectations and perceived self-performance in the expected areas were found to be predictive of career decision-making difficulties. Cultural-value orientation, especially endorsement of Chinese traditional values, was found to moderate the relationship between parental expectation and career decision-making difficulties. Theoretical, research and practical implications of findings were discussed. (Contains 4 tables.)