Argument-Driven Inquiry (ADI) is an instructional model that enables science teachers to transform a traditional laboratory activity into a short integrated instructional unit. To illustrate how the ADI instructional model works, this article describes an ADI lesson developed for a 10th-grade chemistry class. This example lesson was designed to help students understand the nature of chemical reactions and develop the abilities needed to do scientific inquiry. The lesson also gives students an opportunity to improve their writing and verbal communication skills, their understanding of the writing process, and their ability to interpret evidence and reason in a scientific manner. (Contains 3 figures and 1 online resource.)