Introduction: Computers and other technological instruments in general have become a more common practice in our schools nowadays, and Computer-assisted instruction (CAI) has been recently provided in various formats from kindergartens on. It can help children at-risk for learning disabilities. Method: This study investigated the effectiveness of Computer-assisted instruction on enhancing the classification skill in second graders at-risk for learning disabilities. Participants were 68 second graders at risk for learning disabilities from Zagazig, Egypt. They were randomly divided into two matched groups (experimental and control) with 34 participants each. ANCOVA, T-Test, Repeated measure, and scheffe were employed for data analysis. Results: The results indicated that the use of CAI enhanced classification skill in the target participants, i.e. second graders at-risk for learning disabilities. Discussion: Results were discussed, and it was concluded that CAI often leads to substantial gains in at-risk children's early academic skills. (Contains 5 tables.)