This guide is intended for teachers and other educators confronting the challenge of using technology to enhance the way they teach science. Accompanying the recent boom in education Web sites has been the production of guides and guidelines, models, and methodologies for planning technology reforms in school districts, school buildings, and classrooms. On the Internet, there are guides for integrating technology into the curriculum and guides for creating curriculum with technology. "Selecting Computer-Based High School Science Curricula" is different from other resources currently available in that it permits teachers to evaluate whether material offered via the Internet or CD-ROM uses technology to support a sound curriculum. The tool presented in this document provides criteria, in the forms of a questionnaire and a matrix, by which teachers and other educators can determine the suitability of a program offered via a Web site or CD-ROM to serve as a "core curriculum" for high school science. A core curriculum refers here to a curriculum that is the basis of a conventional division of the school calendar (a quarter, semester, or year). The term is applicable to materials developed for any and all of the major science disciplines.