The unique contributions of peer acceptance, friendship, and victimization to adjustment were examined. How these relational systems moderate the influence of one another to influence adjustment was also investigated. Friendship quality, a unique aspect of friendship, was expected to be especially important for adjustment when other relational systems were poor. A total of 238 fifth to eighth graders (boys = 109) participated in the survey-style paradigm. Youth participants completed measures assessing their friendships and peer relationships. Teachers provided assessments of adjustment. Adolescents who had lower levels of peer acceptance, number of friends, and friendship quality had greater teacher-reported maladjustment. Friendship quality was also an important buffer against adjustment problems when peer acceptance and number of friends were low. The outcomes of this article suggest that an approach that includes examining the quality of adolescents' friendships, peer interactions, and interactive models of relationship dimensions are informative for understanding adolescents' general adjustment.