A lot has been learned about effective approaches to realizing intended out-of-school time program outcomes. As program practitioners consider fostering evidence-based practices, program administrators, staff, and stakeholders must keep in mind that it is difficult to change behavior overnight, even among children. Efforts to improve outcomes for children and youth in out-of-school time programs can benefit from implementing proven practices from the field. In this brief, the authors draw from research, as well as a series of Roundtables with practitioners and youth, to identify 10 practices that can foster positive outcomes for participants in out-of-school time programs. In a related brief, they highlight negative practices to avoid.